Super Natural II, a database of natural products. It contains 325,508 natural compounds (NCs), including information about the corresponding
2d structures, physicochemical properties, predicted toxicity class and potential vendors. Natural products are small compounds synthesized by living organisms.
The chemical diversity of these molecules is tremendous and offers inspiration for innovations in medicine, nutrition, agrochemical research and life sciences.
Most of the currently used cosmetics and drugs are either natural products or close derivatives thereof.
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Toxicity via ProTox
Toxic doses are often given as LD50 values in mg/kg body weight.
Toxicity classes are defined according to the globally harmonized system of classification of labelling of chemicals
Class I: fatal if swallowed (LD50 ≤ 5 mg/kg)
Class II: fatal if swallowed (5 < LD50 ≤ 50 mg/kg)
Class III: toxic if swallowed (50 < LD50 ≤ 300 mg/kg)
Class IV: harmful if swallowed (300 < LD50 ≤ 2000 mg/kg)
Class V: may be harmful if swallowed (2000 < LD50 ≤ 5000 mg/kg)
Curcumin is produced by plants of the ginger family, Zingiberaceae. It is a yellow coloured compound.
Curcumin exists in several tautomeric forms. The enol form is more energetically more stable in both, the solid phase and in solution.
It is often used as a food colouring and food additive. Several clinical studies in humans were conducted to the study the effect of curcumin on diseases
like colon cancer, pancreatic cancer and multiple myeloma. The natural properties of this compound makes it an interesting drug candidate.