Promiscuous 2.0

PROMISCUOUS2 is an one stop resource for drug-repositioning. The database can be used from experts by using the drug or target search as well as non experts, by browsing through the data via the Browse tab. Those functions are complemented by with the drug repositioning tab, where users can search for indications or atc-codes and will get "new" drugs proposed for their query.
The aim of this database is to provide a uniform data-set for drug repositioning and further analysis.
Our database PROMISCUOUS2 contains four different types of entities: Drugs, Proteins, side-effects and indications including relations between them for a global view. This is summerised in the network representation (see warfarin example network), where all information are highlighted and linked to the detail sites.

To learn more about the functionality, please have a look at our FAQ site.

Explore Promiscuous:

By Drug:

To search for a drug go to the Drug search Tab and search for a name (e.g. Midodrine) or smiles

By Target:

Targets as for example Fatty acid synthetase can be queried through the Target search site or for example by UniProt ID through the fulltext search as well.

Browse:

Browse for drugs/targets by ICD-10 / ATC Code

Network visualization:

The direct network of drugs is visualized as interactive network.

Drug repositioning:

Search for a drug and get suggestions for drug reposition opportunities.