Promiscuous 2.0

According to references 1-6 (see end of page), 53 drugs were used as reference compounds in order to build a machine learning model based on structural similarity, using the same techniques as described for the drug repositioning in the FAQ.

Please note that the predictions displayed here are intended for research purposes only and in no way to be interpreted as professional medical advice.

Evaluating all drugs contained in Promiscuous 2.0 against the created model led to the following additional compounds predicted as potentially active against Covid-19:




[1] Shaffer L. 15 drugs being tested to treat COVID-19 and how they would work [published online ahead of print, 2020 May 15]. Nat Med. 2020;10.1038/d41591-020-00019-9. doi:10.1038/d41591-020-00019-9

[2] McKee DL, Sternberg A, Stange U, Laufer S, Naujokat C. Candidate drugs against SARS-CoV-2 and COVID-19. Pharmacol Res. 2020;157:104859. doi:10.1016/j.phrs.2020.104859

[3] Wu R, Wang L, Kuo HD, et al. An Update on Current Therapeutic Drugs Treating COVID-19 [published online ahead of print, 2020 May 11]. Curr Pharmacol Rep. 2020;1-15. doi:10.1007/s40495-020-00216-7

[4] Ledford H. Coronavirus breakthrough: dexamethasone is first drug shown to save lives. Nature. 2020;582(7813):469. doi:10.1038/d41586-020-01824-5

[5] Serafin MB, Bottega A, Foletto VS, da Rosa TF, Hörner A, Hörner R. Drug repositioning is an alternative for the treatment of coronavirus COVID-19. Int J Antimicrob Agents. 2020;55(6):105969. doi:10.1016/j.ijantimicag.2020.105969

[6] Altay O, Mohammadi E, Lam S, et al. Current Status of COVID-19 Therapies and Drug Repositioning Applications [published online ahead of print, 2020 Jun 20]. iScience. 2020;23(7):101303. doi:10.1016/j.isci.2020.101303

PID	Name	Score	Used as reference	Drug Details